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Meet the Experts

Randi Hagerman, M.D.
Randi Hagerman, M.D., is a developmental and behavioral pediatrician and the Director of the M.I.N.D. Institute (Medical Investigation of Neurodevelopmental Disorders) at the University of California at Davis Medical Center. An internationally recognized clinician and researcher in developmental and behavioral pediatrics, her area of expertise is fragile X syndrome. She has spent over 20 years conducting clinical work and research on fragile X syndrome, particularly in molecular clinical correlations and treatment endeavors.

Dr. Hagerman has written several books on fragile X syndrome, including a third edition of Fragile X Syndrome: Diagnosis, Treatment and Research, which will be published in 2002 by Johns Hopkins University Press. Dr. Hagerman co-founded the National Fragile X Foundation in Denver, Colorado, in 1984; is presently the chairman of the Scientific and Clinical Advisory Committee of the National Fragile X Foundation; is a scientific advisor to the Conquer Fragile X Foundation; is a scientific reviewer for the FRAXA Foundation; and is on the Advisory Board of both the Northern and the Southern California Fragile X Associations.

In "Living with Fragile X", Dr. Hagerman will explain the science behind fragile X syndrome and reveal the current research into treatment and intervention methods including the ongoing search for a cure.

Stephen T Warren, Ph.D.
Dr. Stephen T. Warren was instrumental in the discovery of the fragile X gene in 1991, and his research into fragile X continues today. He is currently the Chairman of the Department of Human Genetics at Emory University.

Bio and Research Info: Dr. Stephen T. Warren received his PhD in Human Genetics from Michigan State University in 1981. In 2001, Dr, Warren founded the Department of Human Genetics at Emory as the chairman of the Department.

Dr. Warren is a Diplomat of the American Board of Medical Genetics with subspecialty certification in both clinical cytogenetics and clinical molecular genetics. He is a founding Fellow of the American College of Medical Genetics and a member of the Human Genome Organization. Dr. Warren has held various committee memberships in the American Society of Human Genetics and was elected to the Board of Directors in 1997. He serves or has served on the editorial boards of the major journals in human genetics and is the past chairman of the NIH Mammalian Genetics Study Section and of the NIGMS Working Group on the Human Genetic Mutant Cell Repository. Currently he sits on review committees of the March of Dimes and the Muscular Dystrophy Association as well as on advisory groups to NIMH and NICHD. Among his awards are the Albert E. Levy Faculty Award from Emory University, the inaugural William Rosen Research Award from the National Fragile X Foundation and a MERIT award from the NIH.

Paul Hagerman, M.D., Ph.D.
Paul Hagerman, M.D., Ph.D., is a Professor of Biological Chemistry and a M.I.N.D. Institute Investigator at the University of California, Davis, School of Medicine. Dr. Hagerman’s long-standing research interests are in the areas of nucleic acid biochemistry and molecular genetics. Dr. Hagerman is co-editor with his wife, Randi, of the third edition of Fragile X Syndrome: Diagnosis, Treatment and Research.

About three years ago, Dr. Hagerman decided to devote most of his laboratory research effort to finding a treatment or cure for fragile X syndrome. The guiding principle in his research effort is that the gene itself need not be replaced, since it generally codes for a normal protein. Rather, efforts should be directed toward the production of more protein from the existing gene. This approach is also based on several discoveries made in the Hagerman lab over the past two years, including the observation that for a significant fraction of individuals with fragile X, the gene is still at least partially active, even though little or no protein is being produced. Dr. Hagerman is currently working to increase the number of researchers in his laboratory to investigate several possible approaches to treatment.

Louise Gane, Genetic Counselor
Since 1984, Louise Gane has worked with families who have a child or children diagnosed with fragile X syndrome. In 1991, she joined the team led by Dr. Randi Hagerman at the Fragile X Treatment & Research Center in Denver, Colorado as a genetic counselor. Under the directorship of Dr. Randi Hagerman, Louise is now located at the UC Davis M.I.N.D. Institute working as a Genetic Counselor and Assistant to the Director. Louise is involved in counseling patients with fragile X syndrome and their family members: helping them to deal with and understand the diagnosis, assessing genetic risk, and explaining reproductive options. In "Living with Fragile X", Louise will explain the role of the genetic counselor and share her insights into working with children with fragile X, including her thoughts on the importance of genetic testing and diagnosis.

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